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check with blood tests and side-effect review."},"requirement":"routine"},{"purpose":"result_review","after":{"min":56,"max":90,"unit":"days","qualifier":"First response imaging and blood markers; timing depends on agent and cancer type."},"requirement":"routine"}],"indications":["Cancers with molecular targets: HER2, EGFR, ALK, BRAF, BCR-ABL","Hematologic malignancies and solid tumors with a matched targeted agent","Some non-cancer conditions with defined molecular targets"],"main_risks":["Skin reactions such as rash and dryness","Diarrhea, nausea and other gastrointestinal effects","Liver enzyme elevation","Hypertension, cardiac effects or bleeding with certain agents","Infusion reactions with antibody-based agents","Blood count changes"],"pain":"Treatment itself is painless apart from IV cannulation. Side effects such as rash, mouth sores or joint aches are usually mild to moderate.","preparation":["Molecular target or biomarker confirmed by tissue or blood testing","Baseline blood tests and organ function assessment","Review of current medications and supplements with the oncology team","Baseline cardiac or other agent-specific assessment where required","Discussion of expected side effects and contraception where relevant"],"recovery_timeline":[{"phase":"Treatment day","description":"Oral dose started or infusion given with observation for reactions.","restrictions":["Report fever or breathing difficulty immediately","Follow agent-specific food and drug rules"]},{"phase":"First 2 weeks","description":"Early side effects such as rash, diarrhea or fatigue may appear and are managed with supportive care.","restrictions":["Avoid sun exposure","Avoid new supplements without approval"]},{"phase":"Ongoing cycles","description":"Treatment continues with periodic blood tests and imaging to assess response.","restrictions":["Contraception where relevant","Avoid grapefruit with some agents"]}],"rehabilitation_days":{"min":0,"max":3,"unit":"days","qualifier":"Ordinary activity resumes quickly; longer if infusion reactions or fatigue occur."},"result_longevity":"Response lasts as long as the drug is effective, often months to several years. Acquired resistance eventually develops in many cancers.","revision_rate_pct":null,"scars":"No incisions or scars; only minor puncture marks from IV cannulation.","sessions_or_stages":{"sessions":{"min":4,"max":13,"unit":"visits","qualifier":"Infusion-based schedule every 1-3 weeks until first imaging; oral agents need no infusion visits."},"stages":[{"code":"biomarker_confirmation","label":"Biomarker confirmation and baseline tests","after":{"min":0,"max":0,"unit":"days","qualifier":"Before first dose."}},{"code":"treatment_start","label":"First dose or infusion","after":{"min":0,"max":7,"unit":"days","qualifier":"Starts once testing is confirmed."}},{"code":"response_assessment","label":"First response imaging","after":{"min":56,"max":90,"unit":"days","qualifier":"After several cycles."}}],"qualifier":"Treatment continues until progression or intolerance; typical first-phase schedule shown."},"success":{"metric":"Objective tumor response rate at first imaging","value":60,"unit":"percent","horizon":"2-3 months","population":"Adults with biomarker-matched advanced cancer receiving a matched targeted agent","evidence_status":"limited"},"techniques":[{"name":"Small-molecule inhibitors (oral, e.g. tyrosine kinase inhibitors)","suits_whom":"Patients whose tumor carries a matching targetable alteration","recovery":"No recovery period; usually taken continuously at home with periodic monitoring."},{"name":"Monoclonal antibodies (intravenous or subcutaneous)","suits_whom":"Patients with target-expressing tumors such as HER2-positive cancers","recovery":"Given at scheduled infusion visits; usually no recovery time beyond infusion-related effects."},{"name":"Antibody-drug conjugates","suits_whom":"Selected patients with target-expressing cancers and suitable prior treatment history","recovery":"Given at scheduled infusion visits with monitoring for agent-specific toxicity."}],"treatment_conditions":["outpatient"],"treatment_duration_hours":{"min":0.5,"max":3,"unit":"hours","qualifier":"Per infusion visit; first infusion is longest. Oral agents are taken at home."},"initial_assessment_documents":["Pathology report with tumor type and stage","Molecular or genomic testing report","Recent CT or PET-CT scans","Summary of previous cancer treatments","Recent blood test results","Oncologist's latest treatment notes (if available)"],"travel_trips":{"min":2,"max":3,"one_trip_possible":false,"qualifier":"Start visit with first dose and tolerance check, then response imaging at 2-3 months; routine monitoring at home."},"clinic_checks":{"status":"ok","items":[{"id":"C1","text":"Check that your tumor has been tested for the drug's target. Why: the drug is chosen for a specific target found in the tumor","scope":"procedure","source":{"url":"https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet","host":"cancer.gov","quote":"Most of the time, your tumor will need to be tested to see if it contains targets for which there is a drug.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C2","text":"Check the qualifications of the medical team that will treat you","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/using-the-nhs/healthcare-abroad/going-abroad-for-treatment/treatment-abroad-checklist/","host":"nhs.uk","quote":"Have you checked the qualifications of the medical team treating you?","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"C3","text":"Make sure you are clear how your aftercare will be coordinated after treatment 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reconsider","scope":"treatment_abroad","source":{"url":"https://www.nhs.uk/conditions/cosmetic-procedures/cosmetic-surgery-abroad/","host":"nhs.uk","quote":"You should have 2 consultations with the surgeon treating you before any surgery.","tier":"tier1_medical","fetched_at":"2026-11-11","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"red_flags":{"status":"ok","items":[{"id":"F1","text":"Pressure to decide quickly, or cheap time-limited offers to book now","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Don’t be pressured into quick decisions either through forceful persuasion or cheap, time limited offers.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"F2","text":"The doctor you consult may not be the one who actually treats you","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Check that the surgeon you consult with, will be the same person carrying out the procedure.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}},{"id":"F3","text":"Adverts or information promising complete success for the treatment","scope":"treatment_abroad","source":{"url":"https://travelaware.campaign.gov.uk/surgery-abroad-cut-out-the-risk/","host":"travelaware.campaign.gov.uk","quote":"Any advert or information that guarantees complete success should raise concerns.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"warning_signs":{"status":"ok","items":[{"id":"W1","text":"Unusual bleeding or bruising during targeted 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expects","urgency":"contact_clinic","general":true,"source":{"url":"https://mdanderson.org/patients-family/diagnosis-treatment/emotional-physical-effects/targeted-therapy-side-effects.html","host":"mdanderson.org","quote":"A fever higher than what your care team told you to expect","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":200}}],"checked_at":"2026-11-12","next_check_at":"2027-11-12","version":1},"take_home":{"status":"ok","items":[{"id":"T1","text":"Shows which follow-up tests are due and which doctors are responsible for care","document":"written aftercare plan","source":{"url":"https://www.cdc.gov/cancer/survivors/life-after-cancer/survivorship-care-plans.htm","host":"cdc.gov","quote":"Your plan should say when you need to get follow-up tests, and which doctors are responsible for your care.","tier":"tier1_medical","fetched_at":"2026-11-12","http_status":403}},{"id":"T2","text":"Gives the home doctor an up-to-date, clear picture of the treatment 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