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Strenuous exercise after about 3-6 months (autologous) or 6-12 months (allogeneic), if counts and GVHD allow."},"final_result_months":{"min":6,"max":24,"unit":"months","qualifier":"Engraftment takes about 2–4 weeks. Immune recovery and confirmed remission or disease correction take about 6–24 months."},"fly_home_after_days":{"min":30,"max":100,"unit":"days","qualifier":"Autologous: about 4 weeks after infusion, once counts recover. Allogeneic: usually stay near the center until about day +100."},"follow_up_visits":[{"purpose":"assessment","after":{"min":30,"max":45,"unit":"days","qualifier":"Blood count and complication review after discharge; frequent outpatient visits in the first weeks."},"requirement":"routine"},{"purpose":"assessment","after":{"min":90,"max":100,"unit":"days","qualifier":"Day +100 review of GVHD, infections and immunosuppression taper, mainly after allogeneic transplant."},"requirement":"routine"},{"purpose":"result_review","after":{"min":180,"max":365,"unit":"days","qualifier":"Disease restaging and chimerism or marrow assessment to confirm remission and immune recovery."},"requirement":"routine"},{"purpose":"other","after":{"min":30,"max":180,"unit":"days","qualifier":"Unscheduled review if fever, infection, GVHD signs or graft problems arise."},"requirement":"conditional"}],"indications":["Hematologic malignancies such as leukemia, lymphoma and multiple myeloma","Myelodysplastic syndromes and myeloproliferative neoplasms","Bone marrow failure such as severe aplastic anemia","Thalassemia major and sickle cell disease in selected patients","Primary immunodeficiencies","Relapsed or high-risk disease needing high-dose chemotherapy rescue"],"main_risks":["Serious infections due to prolonged immunosuppression","Graft-versus-host disease (allogeneic)","Graft failure requiring a second transplant","Mucositis, nausea and organ toxicity from conditioning","Bleeding and need for transfusions","Veno-occlusive disease of the liver","Infusion reactions","Infertility and late effects including secondary cancers","Transplant-related mortality"],"pain":"The infusion itself is usually painless, similar to a blood transfusion; discomfort mainly comes from conditioning, mouth sores, nausea and other side effects, managed with supportive care.","preparation":["Comprehensive evaluation of disease status, organ function and infection screening","Stem cell collection by apheresis after mobilization (autologous)","Donor HLA matching and donor clearance (allogeneic)","Central venous catheter placement","Conditioning chemotherapy with or without radiation before infusion","Dental and fertility counseling, and arrangement of caregiver support"],"recovery_timeline":[{"phase":"Conditioning and infusion (day -10 to 0)","description":"Conditioning therapy followed by infusion of stem cells over about 30 minutes to a few hours in hospital.","restrictions":["Inpatient protective isolation"]},{"phase":"Aplasia and engraftment (about days 0-30)","description":"Low blood counts until engraftment, with transfusions, infection prophylaxis and supportive care.","restrictions":["Strict infection precautions","Hospital monitoring"]},{"phase":"Early recovery (about 1-3 months)","description":"Frequent outpatient visits, monitoring for infection and graft-versus-host disease, and gradual strength recovery.","restrictions":["Avoid crowds and sick contacts","Food safety precautions","Stay near transplant center"]},{"phase":"Extended recovery (about 3-12 months)","description":"Gradual immune reconstitution; immunosuppression tapered in allogeneic cases; vaccinations restarted per team schedule; slow return to normal activities.","restrictions":["Ongoing infection precautions","Limited sun exposure"]}],"rehabilitation_days":{"min":60,"max":180,"unit":"days","qualifier":"Daily activities resume in about 1–3 months (autologous) or 3–6 months (allogeneic). 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In non-malignant disorders, engraftment can be permanent.","revision_rate_pct":{"min":1,"max":5,"unit":"percent","qualifier":"Second transplant for graft failure, mainly after allogeneic transplant."},"scars":"No surgical scar; only a small mark remains at the central venous catheter site.","sessions_or_stages":{"sessions":{"min":1,"max":1,"unit":"visits","qualifier":"One stem cell infusion within one admission; a second transplant only for graft failure or relapse."},"stages":[{"code":"conditioning","label":"Conditioning chemotherapy with or without radiation","after":{"min":0,"max":0,"unit":"days","qualifier":"Starts about 5-10 days before infusion; counted here as admission start."}},{"code":"stem_cell_infusion","label":"Stem cell infusion","after":{"min":5,"max":10,"unit":"days","qualifier":"Approximate interval after conditioning starts."}}],"qualifier":"One transplant episode: single infusion after conditioning."},"success":{"metric":"Overall survival after 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