Лучшие в мире врачи

Dr. Cengiz Sen is an Orthopedics and Traumatology specialist. He has expertise in revision arthroplasty, degenerative joint disease, congenital limb deformities, and pediatric orthopedic disorders. Dr. Sen is skilled in limb lengthening, pseudoarthrosis surgery, and managing periprosthetic infections. He is also a pioneer in using stem cell therapy for orthopedic conditions.

Dr. Sen has published many articles, especially on total knee replacement and infected nonunion. He is a professor at Istanbul University Faculty of Medicine. He has received the AOTT Oral Presentation Award for his academic and clinical achievements.

Areas of Interests

• Demyelinating Diseases and MS
• Peripheral Neuropathy and Motor Neuron Disease (ALS)
• Neuromuscular Junction Diseases (MG)

Education 

• M.Sc. Faculty of Medicine, Ondokuz Mayıs University  1990
• Specialization in Medicine  Neurology,  Ankara Training and Research Hospital 1997
• Minor Specialization  Clinical Neurophysiology, Medical Specialization Board 2011

Experience

• Doctor MoH Kastamonu and Samsun Health Center No. 7 1990-1992
• Dr. Res.Assist. Ankara Training and Research Hospital Neurology Clinic 1992-1997
• Assoc. Dr. Abant İzzet Baysal University Düzce Faculty of Medicine 1999-2006
• Assoc.Dr. Duzce University Faculty of Medicine 2007-2011
• Prof.Dr  Duzce University Faculty of Medicine  2011-

Dr. Hilmi Apak is a respected pediatric hematology-oncology specialist with more than 21 years of experience. He is trained in pediatric oncology. Dr. Apak has led advanced treatments, including bone marrow transplantation, leukemia chemotherapy, and CAR T-cell therapy.

He has published 75 international medical articles, showing his strong contribution to pediatric oncology research. Dr. Apak has worked as assistant editor for the Turkish Pediatrics Archives Periodical. He has also held important academic and leadership positions, such as Head of Pediatric Hematology-Oncology at Istanbul University-Cerrahpaşa.

Areas of Interests

• Breast cancer
• Lung cancer
• Colorectal cancers
• Gynecological and urogenital cancers
• Molecular Oncology

Education:

• Kızıltepe Anatolian High School 2001
• Dicle University Faculty of Medicine 2007
• Istanbul Medeniyet University Göztepe Training and Research Hospital 2014
• Kartal City Hospital 2021
• Associate Professor of Medical Oncology 2023

Experience:

• Liv Hospital Ulus
• Adıyaman University Training and Research Hospital
• Istanbul Umraniye Training and Research Hospital
• Istanbul Umraniye Training and Research Hospital

Research:

• Phase II, Randomized, Open-Label, Multicenter Study to Comparatively Evaluate the Efficacy and Safety of GDC-9545 and Physician-Preferred Endocrine Monotherapy in Previously Treated, Estrogen Receptor Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer Patients, Other ( International), Dr. Murat Ayhan
• Phase III, Randomized, Evaluating the Efficacy and Safety of Palbociclib and Fulvestrant with Gdc-0077 Compared with Placebo in Patients with Pik3ca-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer. Double Blind, Placebo Controlled Study, Other (International), Dr. Murat Ayhan
• Randomized, Multicenter, Phase Ib/III Study Evaluating the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Atezolizumab Compared to Intravenous Atezolizumab in Patients with Previously Treated Locally Advanced or Metastatic Non-Small Cell Lung Cancer, Other (International) Dr. Murat Ayhan
• Randomized, Controlled, Multicenter, Open-Label Study Including Observation Follow-Up for PSMA-PET-Negative Patients, Investigating the Efficacy and Safety of Addition of Apalutamide to Radiotherapy and LHRH Agonist in PSMA-PET-Positive High-Risk Hormone-Sensitive Prostate Cancer Patients, Other (International) Dr. Murat Ayhan
• Biomarker Study to Identify Patients with Advanced Stage Urothelial Cancer and Fibroblast Growth Factor Receptor Gene Aberrations-42756493BLC0002, Other (International), Dr. Murat Ayhan
• Publications:
• Ayhan M, Turan N, Köstek O, et all. Does the efficacy of regorafenib differ in chemotherapy refractory metastatic colorectal cancer patients who had mucinous pathology compared to those who had non-mucinous pathology? Curr Probl Cancer. 2021 Jun;45(3):100670. doi: 10.1016/j.currproblcancer.2020.100670.
• Ayhan M, Odabas H, Turan N, et all. Factors affecting the mortality rate of patients with cancer hospitalized with COVID-19: a single center's experience. J Chemother. 2021 Nov;33(7):499-508. doi: 10.1080/1120009X.2021.1923153.
• Ayhan M, Laçin Ş, Özyükseler DT, et all. Does systemic anti-tumor therapy increase COVID-19 risk in patients with cancer? J Oncol Pharm Pract. 2021 Sep;27(6):1461-1467. doi: 10.1177/10781552211015762.
• Ayhan M, Abamor E, Coban Kokten S, et al. Value of FDG PET/CT in Predicting Pathologic Complete Response After Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer. EJMI 2022;6(2):165–175.
• Ayhan M, Terzioglu K. Experience With Rapid Drug Desensitization With Chemotherapeutics; A SingleCentre Retrospective Study. EJMI 2021;5(3):380–387.
• Doğan A, AYHAN M. Survival analysis of patients with triple-negative breast cancer: a single-center experience. Journal of Oncological Sciences, 8(2), 94-99., Doi: 10.37047/jos.2022-89749
• Terzioğlu K, Ayhan M. Comparative Assessment of Platinum Salts and Taxane Group Hypersensitivity Reactions, The Role of Skin Tests in Diagnosis? J Oncol Pharm Pract. 2021 Nov 30:10781552211050084. doi: 10.1177/10781552211050084.
• Tacar SY, Selcukbiricik F, Yilmaz M, Erturk K, Murat Sarici A, Gulturk I, Ayhan M, Tural D. Nivolumab for metastatic uveal melanoma: a multicenter, retrospective study. Melanoma Res. 2021 Oct 1;31(5):449-455. doi: 10.1097/CMR.0000000000000744.
• Özyurt E, Özçelik S, Sürmeli H, Çelik M, Ayhan M, Özçelik M. Side effects of immune-checkpoint inhibitors: Can multiple side effects be seen in a patient? J Oncol Pharm Pract. 2022 Mar;28(2):462-465. doi: 10.1177/10781552211038136.
• Dülgar Ö, Öven BB, Atcı MM, Arıkan R, Ay S, Ayhan M, Selvi O, Ozyukseler DT, Bayram E, Özcan E, Yasin Aİ, Gümüş M. Is the benefit of using adjuvant capecitabine in patients with residual triple-negative breast cancer related to pathological response to neoadjuvant chemotherapy? Expert Rev Anticancer Ther. 2022 Jul;22(7):773-780. doi: 10.1080/14737140.2022.2076670.
• Hizal M, Bilgin B, Paksoy N, Ayhan M, et all. The real-life efficacy and safety of osimertinib in pretreated advanced non-small cell lung cancer patients with T790M mutation: a Turkish Oncology Group Study. J Cancer Res Clin Oncol. 2022 Jun;148(6):1501-1508. doi: 10.1007/s00432-021-03748-7.
• Volume I, Kucukarda A, Atcı MM, Ayhan M, et all. Efficacy and safety of trastuzumab emtansine in older patients with HER2-positive advanced breast cancer: a real-world study. Tumori. 2022 Feb;108(1):19-25. doi: 10.1177/03008916211037739.
• Dogan I, Ayhan M, Gurbuz M, et all. The frequency and prognostic significance of ABO/Rh blood groups in male breast cancer patients: A multicenter study. Medicine (Baltimore). 2022 Sep 2;101(35):e30147. doi: 10.1097/MD.0000000000030147.
• Ozcelik M, Oyman A, Cil I, Duzgun O, Ozkan OF, Ayhan M. Cytoreductive Surgery versus Systemic Chemotherapy alone in Isolated Peritoneal Carcinomatosis of Colorectal Origin. J Coll Physicians Surg Pak. 2021 Nov;31(11):1308-1313. doi: 10.29271/jcpsp.2021.11.1308.
• Başoğlu T, Sakin A, Erol C, Ayhan M, et all. Real life experienceof patients with locally advanced gastric and gastroesophageal junction adenocarcinoma treated with neoadjuvant chemotherapy: a Turkish oncology group study. J Chemother. 2022 May 17:1-8. doi: 10.1080/1120009X.2022.2073159.
• Özdemir Ö, Zengel B, Yildiz Y, Ayhan M, et all. The effectiveness and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early-stage human epidermal growth factor receptor 2-positive breast cancer: Turkish Oncology Group study. Anticancer Drugs. 2022 Aug 1;33(7):663-670. doi: 10.1097/CAD.0000000000001310.
• Hizal M, Bilgin B, Paksoy N, Ayhan M, et all. The percentage of ALK-positive cells and the efficacy of first-line alectinib in advanced non-small cell lung cancer: is it a novel factor for stratification? (Turkish Oncology Group Study). J Cancer Res Clin Oncol. 2022 Sep 1. doi: 10.1007/s00432-022-04252-2.
• Hizal M, Bilgin B, Paksoy N, Ayhan M, et all. Real-world data on efficacy and safety of first-line alectinib treatment in advanced-stage, ALK-positive non-small-cell lung cancer patients: a Turkish Oncology Group study. Future Oncol. 2022 Jul;18(23):2573-2582. doi: 10.2217/fon-2022-0083.
• Topcu A, Atci MM, Secmeler S, Besiroglu M, Ayhan M, Ozkan M, Bozkurt O, Urakci Z, Ay S, Geredeli C, Yasin AI, Turk HM. Efficacy of trastuzumab and potential risk factors on survival in patients with HER2-positive metastatic gastric cancer. Future Oncol. 2021 Nov;17(31):4157-4169. doi: 10.2217/fon-2021-0398.
• Bilgin B, Sendur MAN, Yucel S, Ayhan M, et all. Real-life comparison of the afatinib and first-generation tyrosine kinase inhibitors in nonsmall cell lung cancer harboring EGFR exon 19 deletion: a Turk Oncology Group (TOG) study. J Cancer Res Clin Oncol. 2021 Jul;147(7):2145-2152. doi: 10.1007/s00432-020-03501-6.
• Atci MM, Akagunduz B, Demir M, Arikan R, Ay S, Ozer M, Ayhan M, Cil I, Demir N, Ozyurt N, Karakaya G, Cevik GT, Onder AH, Selvi O, Sakin A. The impact of adjuvant oxaliplatin and tumor sidedness on the overall survival of stage IIB colon cancer patients: a multicentre study. J Chemother. 2023 Feb;35(1):19-28. doi: 10.1080/1120009X.2022.2040770.
• Tataroglu Ozyukseler D, Ay S, Turan M, Alkan G, Ayhan M, Surmeli H, et al. The Systemic Inflammation Response Index as a Prognostic Marker in Advanced Pancreatic Cancer. EJMI 2022;6(3):367–373.
• Yıldız F, Ayhan M, Demir H, et all. Comparing the efficacy of cabazitaxel in secondline and third-Line treatment of metastatic castration-resistant prostate cancer: a multi-center experience from Turkey. International Journal of Contemporary Medical Research, 7(9), 112-116.,Doi: 10.21276/ijcmr.2020.7.9.30
• Terzioğlu K, Ayhan M. Distribution of allergens detected on patch tests of patients with allergic contact dermatitis and investigation of their atopic background. Annals of Medical Research, 29(5), 422-426., doi: 10.5455/annalsmedres.2021.07.490
• Arikan R, Atci MM, Ay S, Ayhan M, et all Prognostic significance of mucinous histology in left sided metastatic colorectal cancers with wild type RAS and evaluation of backbone chemotherapy regimens. Oncol Lett. 2023 Apr 5;25(5):208. doi: 10.3892/ol.2023.13795.
• Almuradova E, Yalcin S, Arıkan R, Ayhan M, Demir H, Cevik GT, Karaca M, Petekkaya I, Karabulut B. Survival of Patients With Metastatic Rectum Cancer Who Underwent Metastasectomy Following Conversion Chemotherapy Sans Pelvic Radiotherapy: A Turkish Oncology Group Study. Cureus 2023 May 17;15(5):e39119. doi: 10.7759/cureus.39119.
• Topcu A, Besiroglu M, Atci MM, Ayhan M, et all. Second-line Therapy after Trastuzumab Failure in HER2-Positive Metastatic Gastric Cancer: A Real-life Data. EJMI 2023;7(2):153–161. DOI: 10.14744/ejmi.2023.22720
• Book Writing:
• Drug interactions and side effects of targeted agents, Section name: (Small molecule tyrosine kinase inhibitors; ROS-1 targeted therapies (Crizotinib, Seritinib)) (2021)., AYHAN MURAT, Turkish Clinics Journal of Medical Sciences, Editor: Mehmet Aliustaoglu, Publishing number:1, Number of Pages 92, ISBN:978-625-401- 466-6, Turkish
• Approach to gastrointestinal stromal tumors and neuroendocrine tumors, Department name: (Medical approach in primary non-gastrointestinal neuroendocrine tumors) (2020)., AYHAN MURAT, Akademisyen Yayınevi, Editor: Anılır Ender, Number of editions: 1, Number of Pages 382, ISBN: 9786052585719, Turkish
• Internal medicine emergencies, Department name: (Oncological emergencies) (2022)., YILDIRIM SEDAT, AYHAN MURAT, Efe Academic Publishing, Editor: Serdar Olt, Number of editions: 1, Number of Pages 232, ISBN: 978-625-8324-66- 2, Turkish
• Physicians' chemotherapy cancer drug manual 2020, Section name: (Common chemotherapy regimens in clinical practice) (2022)., SÜMBÜL AHMET TANER, ALKAN ALI, AKSOY ASUDE, AYHAN MURAT, et all, Türkiye Klinikleri Journal of Medical Sciences, Editor: EDWAR CHU, VINCENT T. DEVITA, SAADDETIN KILIÇKAP, CEMIL BILIR, SELÇUK SEBER, Number of editions: 1, Number of pages 772, ISBN: 978-625-401-290- 7, Turkish (Book Translation)

Areas of Interests

• Neuro-oncological surgery
• Spinal Surgery
• Pediatric Neurosurgery
• Peripheral Nerve Surgery
• Functional Neurosurgery and Algology

Education:

• Istanbul University, Faculty of Medicine
• Istanbul Okmeydani Training and Research Hospital

Experience:

• Liv Hospital Ulus
• Sisli Kolan Hospital
• Prof.Dr.Cemil Taşcıoğlu City Hospital
• Ardahan State Hospital

Research:

• Tumor markers and other laboratory findings in brain tumors
• Antiepileptic drugs in operated brain tumors
• Cervical corpectomy techniques
• Pre-emptive analgesia in spine surgeries

Publications:

• Uysal E, Cine HS, Yavuz AY, Cal MA. Impact of subventricular zone interaction on clinical outcomes in patients with intracerebral hematoma. Experimental Biomedical Research, 2024;7(3): 117–126. https://doi.org/10.30714/j-ebr.2024.215
• Çal MA, Yangı K. A Single-center Study Comparing Volumetric and Morphometric Measurements of Chiari Malformation in the Turkish Population. Eur Arc Med Res.2024 Mar;40(1):50-56. doi:10.4274/eamr.galenos.2024.24892.
• Avcı İ, Başkurt O, Şeker S, Kurtuluş Y, Çal MA. Rapid Recurrence of Glioblastoma After 12 Days Despite Gross Total Resection. Eur Arc Med Res.2024 Mar;40(1):62-65. doi:10.4274/eamr.galenos.2024.48615.
• Play MA. The relationship between vertebral compression rates and systemic inflammatory scores in osteoporotic vertebral fractures. Eur Rev Med Pharmacol Sci. 2024;28(3):959-968. doi:10.26355/eurrev_202402_35333
• Çal MA, Gök H. Retrospective Evaluation of the Effect of Surgery and CyberKnife on Recurrence and Neurological Deficits in Cases Diagnosed as Vestibular Schwannoma. Haydarpasa Numune Med J.2023;63 (1), 62 ‑67.doi:10.14744/hnhj.2022.45712
• Uysal E, Çal MA, Cine HS. The use of vancomycin powder in the compound depressed skull fractures. Clin Neurol Neurosurg. 2023;225:107570. doi:10.1016/j.clineuro.2022.107570
• Gök H, Şeker S, Peker HO, Çal MA, Altay T, Çelik S. A rare case report: Cervical subcutaneous and mediastinal emphysema due to mastoid fracture. A rare case report: Cervical subcutaneous and mediastinal emphysema due to mastoid fracture. Ulus Travma Emergency Surgery Journal . 2020;26(2):328 ‑330. doi:10.14744/tjtes.2019.02828
• Çınar N,Karaoğlan A,Midi A,Çal MA,Kelten B,Çakmak MA,Şahin Ş. Neuroprotective effect of ziprasidone: Preliminary results compared to haloperidol. J. Exp. Clin. Med ., 2014; 31:71 ‑75. doi : 10.5835/jecm.omu.31.02.002
• Karaoglan A, Cal MA, Orki A, Arpaozu BM, Colak A. Pneumorrhachis associated with bronchial asthma , subcutaneous emphysema and pneumomediastinum . Turkish Neurosurg . 2011;21(4):666 ‑668.
• Kelten B, Karaoğlan A, Cal MA, Akdemir O, Karancı T. Human immunodeficiency Bilateral epidural puncture in a patient infected with the virus Hematoma : Case report [ Bilateral epidural hematoma in a patient with Human immunodeficiency virus infection : a case report ]. Ulus Trauma Emergency Surgery Journal . 2013;19(3):267 ‑270. doi: 10.5505 /tjtes.2013.49799
• Karaoglan A, Akdemir O, Cinar N, et al. Correlation between leptin and pro- ‑inflammatory cytokines in cortical contusion injury model. Ulus Trauma Emergency Surgery Journal . 2011;17(4):298 ‑302. doi: 10.5505 /tjtes.2011.69077
• Cal MA, Kelten B, Akbas A, Akdemir O, Karaoglan A. Coexistence of spinal lipoma, ependymal cyst and dermoid cyst in neighboring localizations in context medullaris : A case report . HealthMed . 2013; 7(12):3227
• Canpolat A, Duman H, Akbaş A, Çal MA, Akdemir AO. Diffuse dysphagia and myeloradiculopathy presenting idiopathic skeletal hyperosteosis ( Forestier Disease). TC Maltepe University Medical Faculty Journal.2012;4(2),14 ‑17
• Karaoglan A, Kelten B,Akdemir AO,Çal MA. Lumbar spine presenting with radiculopathy spinal Chondroma : Case report. TC Maltepe University Medical Faculty Journal. 2011;3(3),28 ‑30
•  
• Istanbul Medical Chamber
• Turkish Neurosurgery Association
   

Areas of Interests

• Pediatric Genitourinary Reconstrictive Surgery
• Hypospadias
• Circumssion
• Oncological Surgery
• Congenital Abnormalities of Upper and Lower Urinary System
• Newborn Surgery
• Pediatric Abdominal Surgery

Education
 

• 1997 -  19 Mayıs University
• 1998 National Pediatric Surgery Congress Best Reearch Study
• 2001-  Kocaeli University
• 2007 – Kosova Government
• 2009 – Yeditepe University
• 2009 – Suudi Arab be Congeress Best Clinical Study

Experience
 

• FMV Işık Highschool
• İstanbul University Cerrahpaşa Medical Faculty
• Ondokuz Mayıs University
• Zeynep Kamil Childrens Hospital
• Kocaeli University Medical Faculty
• UT Southwestern Medical Center Pediatric Urology, Dallas, USA
• Ege University Medical Center Pediatric Urology
• Yeditepe University

Prof. Dr. Selami Sozubir has authored 65 scientific publications, which have received over 11,000 reads and nearly 1,000 citations, reflecting his strong contribution to the field of pediatric surgery and urology.

Areas of Interests

• Infertility
• In Vitro Fertilization (IVF) Treatment
• Endometriosis
• Urogynecology (urinary incontinence and uterine prolapse surgeries)
• Gynecological Laparoscopic surgeries
• Hysteroscopic surgeries
• Pregnancy Monitoring
• Myoma surgery
• Ovarian cysts and surgeries
• Gynecological plastic surgeries

Education:

• Ataturk University Faculty of Medicine - Undergraduate
• Abant Izzet Baysal University Faculty of Medicine Gynecology and Obstetrics - Specialization
• Bezmialem Vakif University Faculty of Medicine Istanbul - Assistant Professorship
• Bezmialem Vakif University Faculty of Medicine Istanbul - Associate Professorship
• American Hospital - Assisted Reproductive Specialist Training

Experience:

• Bolu Izzet Baysal State Hospital (Compulsory Service) -Bolu
• Bezmialem Vakif University Faculty of Medicine - Istanbul

Education:

• Higher Education (6 Years): Marmara University Faculty of Medicine, 2001
• Specialization in Medicine: Istanbul University Istanbul Faculty of Medicine, 2007
   

Experience:

• Faculty of Medicine, University of Rostock, Department of Cardiac Surgery - Research Assistant, August 2007 - August 2008
• King Faisal Specialist Hospital and Research Center, King Faisal Heart Institute - Fellow, August 2008 - October 2008
• Private Göztepe Şafak Hospital, October 2008 - April 2009
• Private Esnaf Hospital, May 2009 - March 2010
• Düzce Atatürk State Hospital, March 2010 - September 2011
• Private Anadolu Medical Center Hospital, October 2011 - June 2013
• Istanbul University Istanbul Faculty of Medicine, July 2013 - December 2018
• Istanbul Medipol University Faculty of Medicine, January 2019 - April 2023
• Biruni University Faculty of Medicine, April 2023 - Present
•  
• Professor: December 18, 2020
• Associate Professor: April 16, 2015-December 18, 2020
• Specialist Doctor: November 2009- April 16, 2015
• Research assistant: June 2002 - July 2007
• Faculty of Medicine: Marmara University - English (1995-2001)[Diploma Grade: 75/100] - Listed in the World Directory of Medical Schools.

Awards:

Second best oral presentation award: Didem Melis Öztaş, Mert Meriç, Metin Onur Beyaz, Mehmet Akif Onalan, Shiraslan Bakhshaliyev, Kıvılcım Sönmez, Kerem Oter, Sedat Ziyade, Beyhan Ömer, Ufuk Alpagut, Murat Uğurlucan. Investigation of the Effect of Erythropoietin on Stem Cell Levels in Cardiovascular Tissue in Diabetic Rats. 19th National Vascular and Endovascular Surgery Congress, Kyrenia, Cyprus, October 26-29, 2019.

Medical Interests and Activities 

Hepatic Cirrhosis and Portal Hypertension 

Hepatic Cancer 

Viral Hepatitides (Chronic Hepatitis B, C and Delta Infections) 

Alcoholic Chronic Liver Disease 

Non-Alcoholic Fatty Liver Disease 

Stomach and Duodenal Ulcer 

Gastrointestinal Hemorrhage (Ulcer and Varicose Vein Bleeding) 

Functional Digestive System Disorders (Irritable Bowel Syndrome, Functional Intestinal Obstruction and Diarrhea...) 

Inflammatory Bowel Diseases (Ulcerative Colitis, Crohn’s Disease) 

Malabsorption Syndromes (Celiac Disease and Alike) 

Gastrointestinal Tract Malignancies

Education and Experience 

Liv Hospital, Ulus, Gastroenterohepatology Department (2013 ...) 

Associate Professor of Medicine, Obligatory Service at Gastroenterology, Şanlıurfa Training and Research Hospital (2010 - 2012) 

Subspecialty in Gastroenterohepatology, Department of Gastroenterohepatology, İstanbul Faculty of Medicine, İstanbul University (2004 - 2010) 

Research Fellow, Physician, Department of Internal Diseases, 

İstanbul Faculty of Medicine, İstanbul University (1992 - 1998)

Memberships 

Turkish Association For The Study of The Liver 

Turkish Society of Gastroenterology 

Inflammatory Bowel Disease Society 

Internal Diseases Specialty Association

Marmara University Faculty of Dentistry , Istanbul, Turkey 2010 

PHD, Oral Implantology Department of Istanbul University Faculty of Dentistry, Istanbul, 2012